Abstract: The water regulation of Dongjiang River Basin is related to the water supply security and ecological security of Shenzhen, Hong Kong and other places within and outside the basin. The water regulation of the Dongjiang River Basin during the dry season from 2021 to 2022 is faced with problems such as extremely dry incoming water from the basin, serious shortage of water storage in the key reservoirs. Through scientific preparation of regulating plan, implement fine regulation of key reservoirs in combination with rainfall and salinity condition, and strengthening of supervision and management, water supply and ecological security of the basin can be effectively guaranteed. At the same time, the total water consumption of the basin also meets the requirements of annual allocation indicators. In sum, the water regulation of Dongjiang River Basin in dry season from 2021 to 2022 can provide experience reference for water regulation in dry season.