Abstract: Taking the practice of implementing unified and refined water regulation in the Hanjiang River Basin in 2021, which successfully withstood the most severe drought in the past 60 years, as an example, this paper analyzes the control indicators of discharge volume and discharge flow, the backbone water regulation engineering systems, and the water regulation management mode of "regulation scheme, regulation planning, monitoring and early-warning, dynamic regulation, summary and evaluation" for water regulation in the Hanjiang River Basin. Summarizes the water regulation situation in the Hanjiang River Basin in 2021, the drought-fighting water regulation measures taken, as well as the regulation effectiveness of successfully resisting drought and ensuring water supply and ecological security. Analyzed the existing problems and proposed countermeasures and suggestions.The practice of drought-fighting water regulation in Hanjiang River Basin has reference significance for drought-fighting water regulation in other river basins in China.