Abstract: In order to reduce the impact of drought disasters and improve the ability to cope with drought disasters, based on the meteorological and social data of Guangdong Province, selected three evaluation elements of disaster risk, environmental sensitivity and vulnerability to disasters as the criteria layer. On the basis of building the drought risk analysis system, this paper used AHP and GIS to carry out drought risk analysis under the condition of multiple indicators. According to the drought comprehensive risk zoning map of Guangdong Province, the results showed that the risk areas in Guangdong Province presented staggered distribution and the areas (higher than medium risk) accounted for 75.5% of the total area. Based on the analysis of historical disaster data, the risk zoning distribution was basically consistent with the actual situation. The analysis results could provide reference basis for Guangdong Province to effectively cope with drought.