Abstract: The characterization of drought disasters in Central Yunnan Region at multi-century scale is of great significance to formulate the medium-and long-term plan of drought prevention and optimize the layout of regional water network. Based on the drought disaster records in historical documents, reconstructing the sequence of drought disasters in the Central Yunnan Region during the period from 1322 to 2021, and analyzing the characteristics of drought disasters in the Central Yunnan Region in recent 700 years by using wavelet analysis. The results show that Central Yunnan Region drought disasters are prone, phased, seasonal and cyclical, as follows: 366 Central Yunnan Region drought disasters were recorded in historical documents during the 700-year period from 1322 to 2021, with an average of one drought every two years. The frequency of drought disasters increased significantly in the last hundred years, with one mild drought every two years and one severe drought every three years. Under the combined influence of the unique climate and complex terrain conditions, drought disasters occurred seasonally in the low-latitude plateau, mainly in spring and summer, and there are more droughts in spring and summer. The wavelet analysis shows that the drought sequence in the Central Yunnan Region has a main cycle of 365 years, and there are also obvious interdecadal cycles of 44 years and 135 years and interannual cycles of 5 years and 10 years, which can provide scientific basis for Central Yunnan Region drought forecasting.